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KMID : 1039220180280010080
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Journal of Korean Society of Occupational and Environmental Hygiene
2018 Volume.28 No. 1 p.80 ~ p.90
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Recommendation of an Occupational Exposure Limit and Legal Control Following an Acute Hepatotoxicity Incident from HCFC-123
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Lee Kwon-Seob
Jo Ji-Hoon
Choi Bo-Kyung
Lee Hye-Lim
Byeon Sang-Hoon
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Abstract
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Objectives: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard
assessment, calculation of a non-carcinogenicity reference concentration worker(RfCworker) value, and examination of
international agencies’ exposure limits. It also recommends legal management within the Occupational Safety and Health Act for HCFC-123, which caused an acute hepatotoxicity incident.
Methods: An acute hepatotoxicity incident due to the fire extinguishing agent HCFC-123 was investigated. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity RfCworker value was calculated for HCFC-123. An OEL and the necessity of legal management were recommended as well.
Results and Conclusions: An OEL for HCFC-123 of 10 ppm(62.5 ㎎/㎥), which considered the RfCworker value, 5.56 ppm, produced in dose-response assessment and the exposure level of 19.1-20.9 ppm measured as an eight-hour TWA(time-weighted average) in the incident place, is recommended. HCFC-123 is urged to be included as a chemical requiring legal management in the Occupational Safety and Health Regulations. In addition, it is recommended that a peak exposure of ACGIH be adopted in the Notice of the Ministry of Employment and Labor.
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KEYWORD
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HCFC-123, liver disease, no observed adverse effect level(NOAEL), occupational exposure limits(OELs), RfCworker, risk assessment, time-weighted average(TWA)
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